Stability Chambers
Chambers for Accurate and Efficient Stability Testing
Our photostability and stability chambers are designed to meet International Council for Harmonisation (ICH) guidelines for long-term stability testing in pharmaceutical, medical and cosmetic applications. These applications include clinical trials, drug development and commercialization, medical device testing, cosmetic and personal care product testing and many others. The chambers maintain precise control over temperature and humidity to ensure reliable, accurate test results.
Percival’s IntellusUltra control system adapts to almost any programming style. It includes a port that enables access to Supervisory Control and Data Acquisition (SCADA)/Laboratory Information Management System (LIMS) to customize data recording and tracking to ensure compliance with regulations such as 21 CFR Part 11 or GMP Annex 11.
Photostability Tests Completed Within 24 Hours. No Lie.
Percival Scientific manufactures the only chamber capable of completing a full photostability test that meets all requirements of ICH guideline Q1B within 24 hours.
How Do We Do It? It’s Our Advanced LED Lighting.
1. Combined Spectra: Model RX-3000L features proprietary LED panels that integrate the required visible sunlight (6500K) and ultraviolet (UVA) spectra, allowing the two spectral tests to run concurrently rather than sequentially. Several competing chambers use two separate lighting types, such as fluorescent tubes and UV bulbs.
2. Higher Intensity and Uniformity: With a white-light intensity of 52 klux, our chamber can meet the ICH recommendation of 1.2 Mlux in 23.5 hours. And because the lighting uniformity exceeds that of many competing chambers (better than +/-10% across the entire shelf), our chambers provide more usable shelf space, so more product can be tested per run.
Quadruple Your Throughput of High-Quality Testing
Percival photostability chambers, equipped with advanced LED lighting, allow you to test more samples at once and complete tests up to four times faster than other chambers on the market. This not only significantly boosts your testing throughput but also ensures your results meet ICH guidelines, thanks to the proven performance of our products.
Expand Your Testing Capabilities: A Chamber for Forced Degradation and Predictive Stability Studies
We engineered the RX-3600E to extend testing capabilities beyond conventional ICH accelerated stability conditions. With an expanded temperature range of 50–70°C, this chamber creates the precise elevated temperature and humidity conditions required for stress testing described in ICH Q1A(R2), Section 2.1.2, as well as Accelerated Predictive Stability (APS) and Accelerated Stability Assessment Program (ASAP) protocols.
The RX-3600E enables researchers to generate data for predictive stability modeling, specifically those using the humidity-modified Arrhenius equation. This data can provide earlier estimates of chemical stability to guide formulation, packaging and development decisions while complementing conventional ICH stability studies.
Dual ultrasonic and steam humidification systems provide an extensive range of tight humidity control during elevated temperature testing. At 70°C, the optional compressed air dryer package produces low-humidity conditions down to 5% RH, while steam humidification enables high-humidity conditions up to 75% RH.
Compared to conventional stability chambers, the RX-3600E offers researchers a broader range of precisely controlled conditions specifically for forced degradation studies and accelerated predictive stability testing—helping teams gain deeper insights into degradation behavior and make development decisions sooner.
Customizable for Medical, Cosmetic and Pharmaceutical Research
We specialize in customizing environmental chambers and offer optional features to tailor Percival stability chambers to your research needs. We can also collaborate with you to modify your chamber(s) for unique medical, cosmetic and pharmaceutical research requirements.